Quantitative analysis of pulmonary emphysema using local binary patterns

IEEE Trans Med Imaging. 2010 Feb;29(2):559-69. doi: 10.1109/TMI.2009.2038575.

Abstract

We aim at improving quantitative measures of emphysema in computed tomography (CT) images of the lungs. Current standard measures, such as the relative area of emphysema (RA), rely on a single intensity threshold on individual pixels, thus ignoring any interrelations between pixels. Texture analysis allows for a much richer representation that also takes the local structure around pixels into account. This paper presents a texture classification-based system for emphysema quantification in CT images. Measures of emphysema severity are obtained by fusing pixel posterior probabilities output by a classifier. Local binary patterns (LBP) are used as texture features, and joint LBP and intensity histograms are used for characterizing regions of interest (ROIs). Classification is then performed using a k nearest neighbor classifier with a histogram dissimilarity measure as distance. A 95.2% classification accuracy was achieved on a set of 168 manually annotated ROIs, comprising the three classes: normal tissue, centrilobular emphysema, and paraseptal emphysema. The measured emphysema severity was in good agreement with a pulmonary function test (PFT) achieving correlation coefficients of up to |r| = 0.79 in 39 subjects. The results were compared to RA and to a Gaussian filter bank, and the texture-based measures correlated significantly better with PFT than did RA.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • Female
  • Humans
  • Image Interpretation, Computer-Assisted / methods*
  • Lung / diagnostic imaging
  • Male
  • Normal Distribution
  • Pulmonary Emphysema / classification
  • Pulmonary Emphysema / diagnostic imaging*
  • Respiratory Function Tests
  • Severity of Illness Index
  • Smoking
  • Tomography, X-Ray Computed / methods*