Abstract
A new (3) and three known germacrane-type sesquiterpenoids were isolated from the chloroform-soluble fraction of the methanolic extract of the bark of Magnolia kobus (Magnoliaceae) through repeated silica gel and Sephadex LH-20 column chromatography. Their chemical structures were elucidated as costunolide (1), parthenolide (2), isobisparthenolidine (3), and bisparthenolidine (4) by spectroscopic analysis. Compounds 1-4 exhibited cytotoxicity against human A549, SK-OV-3, SK-MEL-2, and HCT15 tumor cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry*
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Antineoplastic Agents, Phytogenic / pharmacology*
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Cell Line, Tumor
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Cell Survival / drug effects
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Chromatography, High Pressure Liquid
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Drug Screening Assays, Antitumor
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Humans
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Magnetic Resonance Spectroscopy
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Magnolia / chemistry*
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Plant Bark / chemistry
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Sesquiterpenes / chemistry*
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Sesquiterpenes / pharmacology*
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Sesquiterpenes, Germacrane / chemistry*
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Sesquiterpenes, Germacrane / pharmacology*
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Spectrophotometry, Infrared
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Spectroscopy, Fourier Transform Infrared
Substances
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Antineoplastic Agents, Phytogenic
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Sesquiterpenes
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Sesquiterpenes, Germacrane
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germacranolide