Association between respiratory and herpes viruses on pulmonary exacerbations in cystic fibrosis patients

J Cyst Fibros. 2010 May;9(3):234-6. doi: 10.1016/j.jcf.2010.02.002. Epub 2010 Mar 2.

Abstract

Respiratory viruses discovered in the 21st century and human herpes viruses (N=13) were seldom (4/50) detected in our cystic fibrosis patients although exacerbation frequency (7.75+/-2.9/a versus 4.45+/-2.1/a; p=0.03) and colonization with Aspergillus fumigatus (RR: 2.6; CI95: 1.8-3.7), Pseudomonas aeruginosa (RR: 1.84; CI95: 1.4-2.4), and Staphylococcus aureus (RR: 1.5; CI95: 1.2-1.9) including MRSA (RR: 4.6; CI95: 1.3-16.6) were associated with virus positivity. Further studies should clarify whether this finding reflects non-specific colonization (human Bocavirus) or reactivation (Epstein-Barr virus) or rather an acceleration of lung tissue inflammation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Child
  • Child, Preschool
  • Cystic Fibrosis / complications*
  • Disease Progression*
  • Female
  • Herpesviridae Infections / complications*
  • Herpesvirus 4, Human / isolation & purification*
  • Human bocavirus / isolation & purification*
  • Humans
  • Infant
  • Male
  • Middle Aged
  • Odds Ratio
  • Parvoviridae Infections / complications*
  • Viral Load
  • Young Adult