Abstract
Sugars and simplified oligosaccharide "mimics" can be joined with protein fragments at pre-defined sites using reliable chemical reactions such as thiol alkylation and Cu(I) catalysed azide/acetylene ligation (click chemistry). These fragments have the potential to be assembled into neoglycoprotein therapeutics using native chemical ligation.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Amino Acid Sequence
-
Biomimetic Materials / chemical synthesis
-
Biomimetic Materials / chemistry
-
Glycopeptides / chemistry*
-
Glycoproteins / chemistry*
-
Models, Molecular
-
Molecular Sequence Data
-
Nitrogen / chemistry*
-
Oligosaccharides / chemistry
-
Protein Conformation
-
Substrate Specificity
-
Sulfur / chemistry*
Substances
-
Glycopeptides
-
Glycoproteins
-
Oligosaccharides
-
Sulfur
-
Nitrogen