Transmission of hemagglutinin D222G mutant strain of pandemic (H1N1) 2009 virus

Emerg Infect Dis. 2010 May;16(5):863-5. doi: 10.3201/eid1605.091815.

Abstract

A pandemic (H1N1) 2009 virus strain carrying the D222G mutation was identified in a severely ill man and was transmitted to a household contact. Only mild illness developed in the contact, despite his obesity and diabetes. The isolated virus reacted fully with an antiserum against the pandemic vaccine strain.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Amino Acid Substitution
  • Disease Outbreaks*
  • Hemagglutinin Glycoproteins, Influenza Virus / genetics*
  • Humans
  • Influenza A Virus, H1N1 Subtype / genetics*
  • Influenza A Virus, H1N1 Subtype / isolation & purification
  • Influenza, Human / epidemiology
  • Influenza, Human / physiopathology
  • Influenza, Human / transmission*
  • Influenza, Human / virology*
  • Male
  • Middle Aged
  • Mutation, Missense*
  • Phylogeny
  • RNA, Viral / analysis
  • RNA, Viral / genetics
  • Retrospective Studies
  • Sequence Analysis, RNA
  • Severity of Illness Index

Substances

  • Hemagglutinin Glycoproteins, Influenza Virus
  • RNA, Viral