TAZ-mediated crosstalk between Wnt and Hippo signaling

Alexander Hergovich; Brian A Hemmings

doi:10.1016/j.devcel.2010.04.003

TAZ-mediated crosstalk between Wnt and Hippo signaling

Dev Cell. 2010 Apr 20;18(4):508-9. doi: 10.1016/j.devcel.2010.04.003.

Authors

Alexander Hergovich¹, Brian A Hemmings

Affiliation

¹ Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland.

PMID: 20412766
DOI: 10.1016/j.devcel.2010.04.003

Abstract

Previously, research addressing Hippo signaling focused on the inactivation of the proto-oncoproteins TAZ and YAP caused by the sequestration of supposedly inactive phospho-TAZ/YAP in the cytoplasm. In this issue of Developmental Cell, the Attisano laboratory now shows that cytoplasmic TAZ inhibits canonical Wnt signaling, thereby highlighting that the Hippo pathway can control other signaling cascades.

Publication types

Comment