BDNF Val66Met polymorphism is associated with aggressive behavior in schizophrenia

G Spalletta; D W Morris; F Angelucci; I A Rubino; I Spoletini; P Bria; G Martinotti; A Siracusano; G Bonaviri; S Bernardini; C Caltagirone; P Bossù; G Donohoe; M Gill; A P Corvin

doi:10.1016/j.eurpsy.2009.10.008

BDNF Val66Met polymorphism is associated with aggressive behavior in schizophrenia

Eur Psychiatry. 2010 Oct;25(6):311-3. doi: 10.1016/j.eurpsy.2009.10.008. Epub 2010 Apr 28.

Authors

G Spalletta¹, D W Morris, F Angelucci, I A Rubino, I Spoletini, P Bria, G Martinotti, A Siracusano, G Bonaviri, S Bernardini, C Caltagirone, P Bossù, G Donohoe, M Gill, A P Corvin

Affiliation

¹ IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, Via Ardetina, 306, 00179 Rome, Italy.

PMID: 20430595
DOI: 10.1016/j.eurpsy.2009.10.008

Abstract

Brain-derived neurotrophic factor (BDNF) gene variants may potentially influence behaviour. In order to test this hypothesis, we investigated the relationship between BDNF Val66Met polymorphism and aggressive behaviour in a population of schizophrenic patients. Our results showed that increased number of BDNF Met alleles was associated with increased aggressive behaviour.

MeSH terms

Adult
Aggression / psychology*
Brain-Derived Neurotrophic Factor / genetics*
Female
Gene Frequency*
Genetic Predisposition to Disease
Humans
Male
Methionine
Middle Aged
Polymorphism, Single Nucleotide
Schizophrenia / genetics*
Schizophrenic Psychology*
Valine

Substances

Brain-Derived Neurotrophic Factor
Methionine
Valine