Abstract
The production of anti-idiotypic antibodies from Epstein-Barr virus transformed peripheral blood lymphocytes was analysed in 12 patients with multiple myeloma and monoclonal gammopathy of undetermined significance. A low anti-idiotype production was found in patients with advanced disease (multiple myeloma stage III), whereas the production was high in patients with multiple myeloma stage I and monoclonal gammopathy of undetermined significance (MGUS) (P less than 0.01). The study supports the existence of an immunological network response in patients with monoclonal gammopathies.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Antibodies, Anti-Idiotypic / analysis*
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Antibodies, Anti-Idiotypic / immunology
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B-Lymphocytes / immunology*
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Enzyme-Linked Immunosorbent Assay
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Humans
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Immunoglobulin A / isolation & purification
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Immunoglobulin Fragments / isolation & purification
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Immunoglobulin G / isolation & purification
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Immunoglobulin M / analysis*
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Lymphocyte Activation / immunology
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Middle Aged
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Multiple Myeloma / immunology
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Multiple Myeloma / pathology
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Neoplasm Staging
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Paraproteinemias / immunology*
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Paraproteinemias / pathology
Substances
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Antibodies, Anti-Idiotypic
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Immunoglobulin A
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Immunoglobulin Fragments
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Immunoglobulin G
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Immunoglobulin M