Neuropsychiatric symptoms in dementia patients with and without a history of traumatic brain injury

J Neuropsychiatry Clin Neurosci. 2010 Spring;22(2):166-72. doi: 10.1176/jnp.2010.22.2.166.

Abstract

The authors aim to determine if a history of traumatic brain injury (TBI) assessed before dementia onset is associated with a higher risk of neuropsychiatric symptoms after dementia onset. A population-based incident series of people with dementia were assessed for TBI prior to onset of dementia and for neuropsychiatric symptoms after the onset, using the Neuropsychiatric Inventory. Participants with predementia TBI were more likely to exhibit disinhibition (12.7% versus 5.4%, OR=2.8, p=0.02), but not other neuropsychiatric symptoms. Traumatic brain injury may increase the risk of disinhibition in patients with dementia.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Aged, 80 and over
  • Alzheimer Disease / epidemiology
  • Alzheimer Disease / genetics
  • Apolipoprotein E4 / genetics
  • Brain Injuries / epidemiology*
  • Brain Injuries / genetics
  • Dementia / epidemiology*
  • Dementia / genetics
  • Female
  • Humans
  • Impulsive Behavior / epidemiology
  • Impulsive Behavior / genetics
  • Logistic Models
  • Male
  • Mental Disorders / epidemiology*
  • Mental Disorders / genetics
  • Neuropsychological Tests
  • Prospective Studies
  • Psychiatric Status Rating Scales
  • Risk Factors
  • Time Factors
  • United States / epidemiology

Substances

  • Apolipoprotein E4