Determination of cyclohexanol in urine and its use in environmental monitoring of cyclohexanone exposure

J Anal Toxicol. 1991 Jan-Feb;15(1):13-6. doi: 10.1093/jat/15.1.13.

Abstract

A simple and sensitive method for determining urinary cyclohexanol, the main metabolite of cyclohexanone, by hydrolysis and gas chromatography (GC) with a flame ionization detector was developed. A 2-mL urine sample was hydrolyzed with 0.4 mL of concentrated HCl and followed by extracting twice with diethylether. Two microL of the filtrate was injected into the GC with a methyl silicone column. The detection limit is estimated to be 0.4 mg/L. The coefficient of variation for the procedure is 8% and 10% for the range of concentration 5 and 50 mg/L, respectively. The within-run variation was 5.4% and between-day variation was 9.67%. The method was verified with urine samples collected from workers exposed to cyclohexanone. An excellent correlation (r = 0.88) was observed between environmental cyclohexanone exposure and cyclohexanol in urine. The procedure is relatively simple and reproducible and it can be applied for occupational health measurement of cyclohexanone exposure.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Calibration
  • Chromatography, Gas
  • Cyclohexanols / urine*
  • Cyclohexanones / urine*
  • Environmental Monitoring / methods*
  • Humans
  • Hydrolysis
  • Occupational Exposure*

Substances

  • Cyclohexanols
  • Cyclohexanones
  • cyclohexanone