Further evidence supporting the association between 5HTR2C gene and bipolar disorder

Marianna Mazza; Laura Mandelli; Giovanni Martinotti; Marco Di Nicola; Daniela Tavian; Gloria Negri; Elisa Colombo; Sara Missaglia; Diana De Ronchi; Roberto Colombo; Luigi Janiri; Alessandro Serretti

doi:10.1016/j.psychres.2009.12.006

Further evidence supporting the association between 5HTR2C gene and bipolar disorder

Psychiatry Res. 2010 Dec 30;180(2-3):151-2. doi: 10.1016/j.psychres.2009.12.006. Epub 2010 May 21.

Authors

Marianna Mazza¹, Laura Mandelli, Giovanni Martinotti, Marco Di Nicola, Daniela Tavian, Gloria Negri, Elisa Colombo, Sara Missaglia, Diana De Ronchi, Roberto Colombo, Luigi Janiri, Alessandro Serretti

Affiliation

¹ Department of Psychiatry, Catholic University, Gemelli Hospital, Rome, Italy.

PMID: 20494452
DOI: 10.1016/j.psychres.2009.12.006

Abstract

Three 5HTR2C polymorphisms were investigated in bipolar (BD) spectrum disorders. The functional rs6318 G (Cys) allele was more frequent in BD patients than in controls (P=0.0036). Thus, 5HTR2C may have a role in BD. Further investigation is required to understand its involvement in co-morbidity for substance use disorders (SUDs).

MeSH terms

Adolescent
Adult
Aged
Aged, 80 and over
Bipolar Disorder / epidemiology
Bipolar Disorder / genetics*
Female
Gene Frequency
Genetic Linkage / genetics
Genotype
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide*
Receptor, Serotonin, 5-HT2C / genetics*
Substance-Related Disorders / epidemiology
Substance-Related Disorders / genetics
Young Adult

Substances

Receptor, Serotonin, 5-HT2C