Urinary type IV collagen excretion predicts subsequent declining renal function in type 2 diabetic patients with proteinuria

Pisut Katavetin; Paravee Katavetin; Paweena Susantitaphong; Natavudh Townamchai; Khajohn Tiranathanagul; Kriang Tungsanga; Somchai Eiam-Ong

doi:10.1016/j.diabres.2010.05.007

Urinary type IV collagen excretion predicts subsequent declining renal function in type 2 diabetic patients with proteinuria

Diabetes Res Clin Pract. 2010 Aug;89(2):e33-5. doi: 10.1016/j.diabres.2010.05.007. Epub 2010 Jun 9.

Authors

Pisut Katavetin¹, Paravee Katavetin, Paweena Susantitaphong, Natavudh Townamchai, Khajohn Tiranathanagul, Kriang Tungsanga, Somchai Eiam-Ong

Affiliation

¹ Division of Nephrology, Department of Medicine, King Chulalongkorn Memorial Hospital, Thai Red Cross Society and Faculty of Medicine, Chulalongkorn University, 1873 Rama IV Road, Pathumwan, Bangkok 10330, Thailand. pkatavetin@yahoo.com

PMID: 20542586
DOI: 10.1016/j.diabres.2010.05.007

Abstract

Baseline urinary type IV collagen excretion was negatively correlated with the subsequent GFR change (r(s)=-0.39, p=0.04) in our cohort of 30 type 2 diabetic patients with proteinuria. Therefore, it could be used to predict subsequent declining renal function in type 2 diabetic patients with proteinuria.

MeSH terms

Adult
Aged
Aged, 80 and over
Angiotensin-Converting Enzyme Inhibitors / therapeutic use
Collagen Type IV / urine*
Diabetes Mellitus, Type 2 / drug therapy
Diabetes Mellitus, Type 2 / physiopathology*
Diabetes Mellitus, Type 2 / urine*
Diabetic Nephropathies / pathology*
Diabetic Nephropathies / urine*
Female
Glomerular Filtration Rate
Humans
Kidney Function Tests
Male
Middle Aged
Proteinuria / drug therapy
Proteinuria / pathology*
Proteinuria / urine*

Substances

Angiotensin-Converting Enzyme Inhibitors
Collagen Type IV