Highly flexible synthesis of chiral azacycles via iridium-catalyzed hydrogenation

J Am Chem Soc. 2010 Jul 7;132(26):8880-1. doi: 10.1021/ja103901e.

Abstract

A range of saturated chiral azacycles has been prepared in high yield and with high selectivity from simple starting materials. A modular approach with ring-closing metathesis as a key step was used to produce a number of five-, six-, and seven-membered cyclic alkenes. Asymmetric hydrogenation catalyzed by N,P-ligated iridium complexes gave saturated azacycles in high optical purity. This methodology was demonstrated in the synthesis of a pharmaceutical precursor.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkenes / chemistry
  • Aza Compounds / chemical synthesis*
  • Aza Compounds / chemistry*
  • Catalysis
  • Hydrogenation
  • Iridium / chemistry*
  • Pyridines / chemistry
  • Stereoisomerism
  • Substrate Specificity
  • Tosyl Compounds / chemistry

Substances

  • Alkenes
  • Aza Compounds
  • Pyridines
  • Tosyl Compounds
  • Iridium
  • pyridine