[Macrophage activation syndrome as the presenting feature of a Hodgkin's lymphoma in an elderly patient]

C Martinaud; J-M Cournac; S Pons; T Gaillard; C Darles; J-P de Jaureguiberry; P Brisou

doi:10.1016/j.revmed.2010.03.460

[Macrophage activation syndrome as the presenting feature of a Hodgkin's lymphoma in an elderly patient]

Rev Med Interne. 2011 Feb;32(2):e15-7. doi: 10.1016/j.revmed.2010.03.460. Epub 2010 Jun 2.

[Article in French]

Authors

C Martinaud¹, J-M Cournac, S Pons, T Gaillard, C Darles, J-P de Jaureguiberry, P Brisou

Affiliation

¹ Fédération des laboratoires, HIA Sainte-Anne, 2, boulevard Sainte-Anne, BP 20545, 83041 Toulon cedex 9, France. christophe.martinaud@inserm.fr

PMID: 20627476
DOI: 10.1016/j.revmed.2010.03.460

Abstract

Macrophage activation syndrome (MAS) is a rare immunological disorder, rapidly life-threatening in the absence of specific treatment. Malignant lymphoma is common cause of MAS, but Hodgkin's lymphoma has been rarely associated with MAS. We report a 79-year-old man who presented a MAS as the presenting feature of Hodgkin's lymphoma, with a rapidly fatal outcome. We discuss the usefulness of sCD25 and interleukine 18 assays when diagnosis is difficult to obtain. We also review the literature data related to Hodgkin's lymphoma-associated MAS.

Publication types

Case Reports
English Abstract

MeSH terms

Aged
Fatal Outcome
Hodgkin Disease / diagnosis*
Humans
Macrophage Activation Syndrome / etiology*
Male