Notch regulation of early thymocyte development

Semin Immunol. 2010 Oct;22(5):261-9. doi: 10.1016/j.smim.2010.04.015. Epub 2010 Jul 13.

Abstract

Notch signaling plays multiple roles in T cell development. Following thymic entry, Notch signals are required to specify the T cell fate from a multipotent hematopoietic progenitor. At subsequent steps in early T cell development, Notch provides important differentiation, survival, proliferation and metabolic signals. This review focuses on the multiple functions of Notch in early T cell development, from T cell specification in the thymus through beta selection.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Differentiation*
  • Humans
  • Protein Binding
  • Receptors, Antigen, T-Cell / immunology
  • Receptors, Antigen, T-Cell / metabolism
  • Receptors, Notch / immunology*
  • Receptors, Notch / metabolism
  • Signal Transduction*
  • Thymus Gland / cytology*
  • Thymus Gland / immunology*
  • Thymus Gland / metabolism

Substances

  • Receptors, Antigen, T-Cell
  • Receptors, Notch