[3-azabicyclo[3.1.0]hex-1-yl]phenyl-benzenesulfonamides as selective dopamine D3 antagonists

Bioorg Med Chem Lett. 2010 Sep 15;20(18):5491-4. doi: 10.1016/j.bmcl.2010.07.073. Epub 2010 Jul 21.

Abstract

A new class of azabicyclo[3.1.0]benzenesulfonamides is presented as selective dopamine D3 antagonists together with SAR and selectivity data.

MeSH terms

  • Benzene / chemistry
  • Benzene / pharmacology
  • Dopamine Antagonists / chemistry*
  • Dopamine Antagonists / pharmacology*
  • Humans
  • Receptors, Dopamine D3 / antagonists & inhibitors*
  • Receptors, Dopamine D3 / metabolism*
  • Structure-Activity Relationship
  • Sulfonamides / chemistry*
  • Sulfonamides / pharmacology*

Substances

  • Dopamine Antagonists
  • Receptors, Dopamine D3
  • Sulfonamides
  • Benzene