Abstract
The review (with 214 references cited) is devoted to moenomycins, the only known group of antibiotics that directly inhibit bacterial peptidoglycan glycosytransferases. Naturally occurring moenomycins and chemical and biological approaches to their derivatives are described. The biological properties of moenomycins and plausible mechanisms of bacterial resistance to them are also covered here, portraying a complete picture of the chemistry and biology of these fascinating natural products
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Anti-Bacterial Agents* / biosynthesis
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Anti-Bacterial Agents* / chemical synthesis
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Anti-Bacterial Agents* / chemistry
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Anti-Bacterial Agents* / pharmacology
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Disease Models, Animal
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Glycosyltransferases / antagonists & inhibitors*
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Gram-Negative Bacteria / drug effects
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Gram-Positive Bacteria / drug effects
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Mice
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Microbial Sensitivity Tests
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Molecular Structure
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Oligosaccharides* / biosynthesis
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Oligosaccharides* / chemical synthesis
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Oligosaccharides* / chemistry
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Oligosaccharides* / pharmacology
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Streptomyces / chemistry
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Streptomyces / metabolism
Substances
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Anti-Bacterial Agents
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Oligosaccharides
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Glycosyltransferases
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moenomycin