Abstract
Abstract We address the issue of the potential for malignant transformation of cultured mesenchymal stromal cells (MSC) commonly used in clinical cell-therapy protocols and describe the culture conditions under which tumorigenesis is likely to be an extremely uncommon event.
MeSH terms
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Adult Stem Cells / metabolism*
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Adult Stem Cells / pathology
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Animals
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Biomarkers, Tumor / genetics
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Biomarkers, Tumor / metabolism
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Cell Culture Techniques
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Cell Proliferation
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Cell Transformation, Neoplastic*
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Cellular Senescence
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Clinical Trials as Topic
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Humans
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Mesenchymal Stem Cell Transplantation / adverse effects*
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Mesenchymal Stem Cells / metabolism*
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Mesenchymal Stem Cells / pathology
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Mice
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Risk Factors
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Stromal Cells / metabolism*
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Stromal Cells / pathology
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Stromal Cells / transplantation
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Telomerase / genetics
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Telomerase / metabolism
Substances
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Biomarkers, Tumor
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Telomerase