[Biotransformation and pharmacokinetics of AWD 26-06, 8-chloro-5,10-dihydro-5-[bis(2-hydroxyethyl)aminoacetyl]-11H-dibenzo[d, c][1,4]diazepin-11-one hydrochloride in the rat]

Pharmazie. 1990 Jul;45(8):603-7.
[Article in German]

Abstract

After p.o. administration to rats AWD 26-06 (1) is rapidly but incompletely absorbed. The relatively short distribution (t1/2 alpha = 37 min) is followed by a middle-long elimination (t1/2 beta = 14 h). The volumen of distribution do not suggest an uncommon accumulation in deep compartments. About 70% of 1 were excreted unchanged with the feces. In urine and feces 18 metabolites were identified. The structure of 10 products could be elucidated. All metabolites have changed side-chains. Furthermore, the tricyclic molecule without side-chain and a N-methyl derivative were identified. The metabolites with so far unknown structure contain the unsubstituted tricyclic moiety too.

Publication types

  • English Abstract

MeSH terms

  • Animals
  • Biotransformation
  • Dibenzazepines / metabolism*
  • Dibenzazepines / pharmacokinetics
  • Dibenzazepines / urine
  • Feces / chemistry
  • Male
  • Rats
  • Rats, Inbred Strains
  • Spectrophotometry, Ultraviolet

Substances

  • Dibenzazepines
  • AWD 26-06