[Annular elastolytic giant-cell granuloma]

Ann Dermatol Venereol. 2010 Aug-Sep;137(8-9):532-5. doi: 10.1016/j.annder.2009.04.014. Epub 2009 May 28.
[Article in French]

Abstract

Background: Annular elastolytic giant-cell granuloma (AEGCG) is a rare form of granulomatous dermatosis characterized by annular plaques with central atrophy and raised erythematous margins and is usually located on the facial and neck areas. It is characterized histologically by loss of elastic fibre and elastophagocytosis. We report a case of AEGCG.

Case report: A 72-year-old man consulted for annular plaques, some of which were atrophic, and papules that had been present for 2 years. The lesions involved sun-exposed and non-sun-exposed skin. The biopsies showed granulomatous infiltrates and discrete elastophagocytosis. After ruling out various differential clinical and histological diagnoses, the patient was diagnosed with AEGCG.

Discussion: We report a case of AEGCG. Diagnosis was not easy. The differential diagnoses of this entity were discussed and we ruled out actinic granuloma, sarcoidosis, leprosy, and granuloma annulare. Our patient presented the classical annular variant combined with a papular variant. We report the first case involving response to isotretinoin.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Aged
  • Elastic Tissue / pathology*
  • Elastin / metabolism
  • Facial Dermatoses / diagnosis
  • Facial Dermatoses / drug therapy
  • Facial Dermatoses / pathology
  • Granuloma Annulare / diagnosis*
  • Granuloma Annulare / drug therapy
  • Granuloma Annulare / pathology
  • Granuloma, Giant Cell / diagnosis*
  • Granuloma, Giant Cell / drug therapy
  • Granuloma, Giant Cell / pathology
  • Hand Dermatoses / diagnosis
  • Hand Dermatoses / drug therapy
  • Hand Dermatoses / pathology
  • Humans
  • Isotretinoin / therapeutic use
  • Male
  • Models, Biological
  • Phagocytosis
  • Remission Induction

Substances

  • Elastin
  • Isotretinoin