[Molecular principles of tau-induced toxicity: new experimental therapy strategies for treatment of Alzheimer's disease]

Nervenarzt. 2010 Nov;81(11):1289-90, 1292, 1294, passim. doi: 10.1007/s00115-010-3052-2.
[Article in German]

Abstract

Neurofibrillary tangles are the hallmark of Alzheimer's disease together with amyloid plaques. They are composed of hyperphosphorylated and aggregated Tau proteins. Consequently, experimental disease modifying approaches include kinase and aggregation inhibitors as well as substances which increase degradation of Tau proteins.

Publication types

  • English Abstract

MeSH terms

  • Aged
  • Aged, 80 and over
  • Alzheimer Disease / drug therapy*
  • Alzheimer Disease / metabolism*
  • Amyloid Precursor Protein Secretases / antagonists & inhibitors
  • Amyloid beta-Peptides / metabolism*
  • Brain / metabolism*
  • Glycogen Synthase Kinase 3 / antagonists & inhibitors
  • Humans
  • Immunotherapy
  • Neurotransmitter Agents / therapeutic use*
  • tau Proteins / metabolism*

Substances

  • Amyloid beta-Peptides
  • Neurotransmitter Agents
  • tau Proteins
  • Glycogen Synthase Kinase 3
  • Amyloid Precursor Protein Secretases