Malnutrition in patients treated for oral or oropharyngeal cancer--prevalence and relationship with oral symptoms: an explorative study

Support Care Cancer. 2011 Oct;19(10):1675-83. doi: 10.1007/s00520-010-1001-z. Epub 2010 Sep 16.

Abstract

Purpose: This study aimed to assess prevalence of malnutrition after treatment for oral/oropharyngeal cancer and to explore how oral symptoms relate to malnutrition after treatment.

Methods: In this cross-sectional study, malnutrition (weight loss ≥ 10% in 6 months or ≥ 5% in 1 month), oral symptoms (EORTC QLQ-H&N35 questionnaire and additional questions to assess chewing problems), dental status, trismus and dietary intake were assessed in 116 adult patients treated for oral/oropharyngeal cancer.

Results: Prevalence of malnutrition was 16% (95%CI: 10% to 23%). Prevalence of malnutrition in the period 0-3 months after treatment was significantly higher (25%) than in the periods >3-12 months (13%) and >12-36 months after treatment (3%, p = 0.008). Logistic multivariate regression analysis revealed that swallowing problems (p = 0.021) and insufficient protein intake were significantly related to malnutrition (p = 0.016).

Conclusions: In conclusion, malnutrition is a considerable problem in patients treated for oral/oropharyngeal cancer, shortly after treatment. Of all oral symptoms, only swallowing problems were significantly related to malnutrition in the period after treatment for oral/oropharyngeal cancer.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Cross-Sectional Studies
  • Deglutition Disorders / etiology
  • Dietary Proteins
  • Female
  • Follow-Up Studies
  • Humans
  • Logistic Models
  • Male
  • Malnutrition / epidemiology*
  • Malnutrition / etiology
  • Middle Aged
  • Mouth Neoplasms / complications*
  • Mouth Neoplasms / pathology
  • Mouth Neoplasms / therapy
  • Multivariate Analysis
  • Oropharyngeal Neoplasms / complications*
  • Oropharyngeal Neoplasms / pathology
  • Oropharyngeal Neoplasms / therapy
  • Prevalence
  • Surveys and Questionnaires
  • Time Factors

Substances

  • Dietary Proteins