Potent inhibition of HIV-1 entry with a chemically programmed antibody aided by an efficient organocatalytic synthesis

Chembiochem. 2010 Oct 18;11(15):2113-8. doi: 10.1002/cbic.201000432.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Catalytic / chemistry*
  • Benzoates / chemistry*
  • CCR5 Receptor Antagonists
  • Catalysis
  • Cell Line
  • Diketopiperazines
  • Fluorescent Dyes / chemistry
  • Fructose-Bisphosphate Aldolase / chemistry*
  • Fructose-Bisphosphate Aldolase / immunology
  • HIV Envelope Protein gp120 / chemistry
  • HIV Fusion Inhibitors / chemistry*
  • HIV-1 / drug effects
  • Humans
  • Immunoglobulin Fab Fragments / chemistry*
  • Piperazines / chemistry*
  • Proline / chemistry
  • Protein Binding
  • Receptors, CCR5 / metabolism
  • Rhodamines / chemistry
  • Simian Immunodeficiency Virus / drug effects
  • Spiro Compounds / chemistry*

Substances

  • Antibodies, Catalytic
  • Benzoates
  • CCR5 Receptor Antagonists
  • Diketopiperazines
  • Fluorescent Dyes
  • HIV Envelope Protein gp120
  • HIV Fusion Inhibitors
  • Immunoglobulin Fab Fragments
  • Piperazines
  • Receptors, CCR5
  • Rhodamines
  • Spiro Compounds
  • gp120 protein, Human immunodeficiency virus 1
  • aplaviroc
  • Proline
  • antibody aldolase
  • Fructose-Bisphosphate Aldolase