Ziwu-liuzhu (Midnight-noon Ebb-flow) acupuncture therapy is a natural therapy by taking the time as a princi-Ziwu-liuzhu (Midnight-noon Ebb-flow) acupuncture therapy is a natural therapy by taking the time as a principal condition. It has been being widely applied in clinical practice. In the present paper, the authors review the progress of clini-pal condition. It has been being widely applied in clinical practice. In the present paper, the authors review the progress of clinical application and related researches on Midnight-noon Ebb-flow acupuncture method in the past years, and also summarize some scholars' opinions about its extent problems and shortcomings.