Gd-complexes of macrocyclic DTPA conjugates of 1,1'-bis(amino)ferrocenes as high relaxivity MRI blood-pool contrast agents (BPCAs)

Chem Commun (Camb). 2010 Nov 28;46(44):8442-4. doi: 10.1039/c0cc03145c. Epub 2010 Oct 1.

Abstract

We report the synthesis of macrocyclic DTPA conjugates of 1,1'-bis(amino)ferrocenes (1a-b) and their Gd-complexes [Gd(L)(H(2)O)] (2a-b, L = 1a-b) for use as new MRI blood-pool contrast agents. High R(1) relaxivity in HSA as well as high thermodynamic and kinetic stabilities is observed for 2a.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Contrast Media / chemical synthesis*
  • Contrast Media / chemistry
  • Contrast Media / pharmacokinetics
  • Coordination Complexes / chemical synthesis*
  • Coordination Complexes / chemistry
  • Coordination Complexes / pharmacokinetics
  • Ferrous Compounds / chemistry*
  • Gadolinium / chemistry*
  • Humans
  • Kinetics
  • Macrocyclic Compounds / chemistry*
  • Magnetic Resonance Imaging
  • Metallocenes
  • Pentetic Acid / chemistry*
  • Rats
  • Serum Albumin / chemistry
  • Thermodynamics

Substances

  • Contrast Media
  • Coordination Complexes
  • Ferrous Compounds
  • Macrocyclic Compounds
  • Metallocenes
  • Serum Albumin
  • Pentetic Acid
  • Gadolinium
  • ferrocene