Efficient synthesis of 1-sulfonyl-1,2,3-triazoles

Org Lett. 2010 Nov 5;12(21):4952-5. doi: 10.1021/ol102087r.

Abstract

An efficient room-temperature method for the synthesis of 1-sulfonyl-1,2,3-triazoles from in situ generated copper(I) acetylides and sulfonyl azides is described. The copper(I) thiophene-2-carboxylate (CuTC) catalyst produces the title compounds under both nonbasic anhydrous and aqueous conditions in good yields.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Copper / chemistry
  • Ligands
  • Molecular Structure
  • Sulfones / chemistry*
  • Triazoles / chemical synthesis*

Substances

  • Ligands
  • Sulfones
  • Triazoles
  • Copper