[Unknown gonadotoxicity chemotherapy and preservation of fertility: example of Temozolomide]

Abstract

Objectives: To evaluate the effect of Temozolomide on female fertility and the relevance of our coverage in preservation of fertility.

Patients and methods: From 2005 to 2009, 24 patients treated with Temozolomide for a low-grade glioma were included in the study (12 women who underwent a fertility preservation consultation and 12 women who did not). A retrospective study of their medical records and sending a questionnaire were undertaken to assess their fertility after treatment.

Results: Of the 24 patients, 15 patients had no fertility preservation and the remaining nine had a cryopreservation of embryos with or without an oocyte cryopreservation. Four patients are or have been pregnant (delivery, spontaneous miscarriage, pregnancy being in the group of preserving fertility and a current pregnancy in the group where no fertility preservation has been achieved).

Discussion: First study on the effect of Temozolomide on female fertility.

Conclusion: Temozolomide is not totally gonadotoxic.