[The prevalence of arrhythmias and repolarization changes in patients with mild or moderate essential hypertension undergoing an exercise test. Their variations with different antihypertensive treatments]

An Med Interna. 1990 Nov;7(11):565-9.
[Article in Spanish]

Abstract

42 mild and moderate hypertensive patients treated with Verapamil, Atenolol and Xipamide were studied. Exercise tests (ET) were performed at the onset and after a month of therapy, in order to detect arrhythmias and repolarization change prevalence of ventricular arrhythmias (VA) was 23.7% and 11.9% for supraventricular arrhythmias (SVA). 45.2% of the exercise tests were considered positive, with a significant correlation with maximum pressure peak. Patients with left ventricular hypertrophy (LVH) showed a significant increase in VA and +ET prevalence (42.1% and 63.2%). After treatment, the prevalence for VA registered a slight decrease and an increase for SVA; these differences not being considered significant. +ET showed a significant decrease in all patients, as well as in those with previous LVH (21.4%, 26.3%). Only atenolol produced a significant decrease in the +ET of patients with previous LVH (75% to 12.5%).

Publication types

  • Clinical Trial
  • Comparative Study
  • English Abstract
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Antihypertensive Agents / therapeutic use*
  • Arrhythmias, Cardiac / epidemiology*
  • Arrhythmias, Cardiac / etiology
  • Arrhythmias, Cardiac / physiopathology
  • Atenolol / therapeutic use
  • Drug Evaluation
  • Echocardiography
  • Exercise Test
  • Humans
  • Hypertension / complications*
  • Hypertension / drug therapy
  • Hypertension / physiopathology
  • Middle Aged
  • Physical Exertion / drug effects
  • Physical Exertion / physiology*
  • Prevalence
  • Verapamil / therapeutic use
  • Xipamide / therapeutic use

Substances

  • Antihypertensive Agents
  • Xipamide
  • Atenolol
  • Verapamil