We have calibrated the x-ray response of a variable line spaced grating spectrometer, known as the VSG, at the Fusion and Astrophysics Data and Diagnostic Calibration Facility at the Lawrence Livermore National Laboratory (LLNL). The VSG has been developed to diagnose laser produced plasmas, such as those created at the Jupiter Laser Facility and the National Ignition Facility at LLNL and at both the Omega and Omega EP lasers at the University of Rochester's Laboratory for Laser Energetics. The bandwidth of the VSG spans the range of ∼6-60 Å. The calibration results presented here include the VSG's dispersion and quantum efficiency. The dispersion is determined by measuring the x rays emitted from the hydrogenlike and heliumlike ions of carbon, nitrogen, oxygen, neon, and aluminum. The quantum efficiency is calibrated to an accuracy of 30% or better by normalizing the x-ray intensities recorded by the VSG to those simultaneously recorded by an x-ray microcalorimeter spectrometer.