Abstract
A description is given of the results of neutron diffraction studies of the structures of four different metal-ion complexes of deuterated D-xylose isomerase. These represent four stages in the progression of the biochemical catalytic action of this enzyme. Analyses of the structural changes observed between the various three-dimensional structures lead to some insight into the mechanism of action of this enzyme.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Aldose-Ketose Isomerases / chemistry*
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Aldose-Ketose Isomerases / metabolism*
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Catalysis
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Deuterium Oxide / metabolism
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Hydrogen
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Metals / chemistry
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Metals / metabolism*
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Models, Molecular
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Neutron Diffraction*
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Neutrons*
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Protein Conformation
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Protons
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Xylulose / metabolism*
Substances
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Metals
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Protons
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Xylulose
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Hydrogen
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Aldose-Ketose Isomerases
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xylose isomerase
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Deuterium Oxide