[The expressional alterations of CSF-1R after ischemic injury of cerebral cortex]

Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2008 Feb;24(1):6-9.
[Article in Chinese]

Abstract

Aim: To observe the expressional alterations of colony stimulating factor-1 receptor (CSF-1R) after ischemic injury of cerebral cortex, and study the function of colony stimulating factor-1 (CSF-1)/CSF-1R signal during the process of ischemic injury and repair of central nervous system (CNS).

Methods: We examined the distribution and expression of CSF-1R in normal brain tissues and ischemic brain tissues by immunohistology and Western blot analysis.

Results: The expression of CSF-1R in neurons could be up-regulated by ischemic injury in CNS.

Conclusion: CSF-1/CSF-1R might take part in the process of ischemic injury and repair.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brain Ischemia / pathology
  • Brain Ischemia / physiopathology
  • Cerebral Cortex / blood supply*
  • Female
  • Macrophage Colony-Stimulating Factor / physiology*
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Neurons / metabolism
  • Random Allocation
  • Receptor, Macrophage Colony-Stimulating Factor / genetics
  • Receptor, Macrophage Colony-Stimulating Factor / metabolism*
  • Receptor, Macrophage Colony-Stimulating Factor / physiology
  • Reperfusion Injury / metabolism*
  • Reperfusion Injury / physiopathology

Substances

  • Macrophage Colony-Stimulating Factor
  • Receptor, Macrophage Colony-Stimulating Factor