Is there a role of p53 codon 72 polymorphism in the susceptibility to type 2 diabetes in overweight subjects? A study in patients with cardiovascular diseases

F Gloria-Bottini; M Banci; P Saccucci; A Magrini; E Bottini

doi:10.1016/j.diabres.2010.11.031

Is there a role of p53 codon 72 polymorphism in the susceptibility to type 2 diabetes in overweight subjects? A study in patients with cardiovascular diseases

Diabetes Res Clin Pract. 2011 Mar;91(3):e64-7. doi: 10.1016/j.diabres.2010.11.031. Epub 2010 Dec 13.

Authors

F Gloria-Bottini¹, M Banci, P Saccucci, A Magrini, E Bottini

Affiliation

¹ Department of Biopathology and Imaging Diagnostics, University of Rome Tor Vergata, Rome, Italy. gloria@med.uniroma2.it

PMID: 21146884
DOI: 10.1016/j.diabres.2010.11.031

Abstract

Two hundred and eighty six subjects with cardiovascular diseases and 147 healthy newborns were studied. P53 codon 72 polymorphism was determined by DNA analysis. The association between BMI and diabetes depends on p53 polymorphism: Odds Ratio shows a high significant association between BMI and diabetes in *Arg/*Arg subjects (p=0.00001). No significant association is observed in *Pro allele carriers (p=0.203).

MeSH terms

Aged
Body Mass Index
Cardiovascular Diseases / complications
Cardiovascular Diseases / genetics*
Codon
Diabetes Mellitus, Type 2 / complications
Diabetes Mellitus, Type 2 / genetics*
Female
Genes, p53 / genetics*
Genetic Predisposition to Disease*
Humans
Infant, Newborn
Male
Middle Aged
Overweight / genetics*
Polymorphism, Genetic*

Substances

Codon