20-HETE in acute kidney injury

Kidney Int. 2011 Jan;79(1):10-3. doi: 10.1038/ki.2010.396.

Abstract

Ischemia/reperfusion injury (IRI) is a common cause of acute kidney injury (AKI) that is associated with a patient mortality of up to 50%. Currently there are not effective pharmacologic therapies for AKI. This Commentary highlights recent evidence indicating that 20-HETE plays an important role in IRI and that drugs that target this pathway have potential as therapeutic agents for AKI.

Publication types

  • Comment
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Kidney Injury / drug therapy*
  • Acute Kidney Injury / etiology*
  • Acute Kidney Injury / physiopathology
  • Animals
  • Humans
  • Hydroxyeicosatetraenoic Acids / antagonists & inhibitors*
  • Hydroxyeicosatetraenoic Acids / metabolism*
  • Hydroxyeicosatetraenoic Acids / therapeutic use
  • Rats
  • Reperfusion Injury / complications*

Substances

  • 20-hydroxyeicosa-6(Z),15(Z)-dienoic acid
  • Hydroxyeicosatetraenoic Acids
  • 20-hydroxy-5,8,11,14-eicosatetraenoic acid