Immunogenicity of single dose live attenuated hepatitis a vaccine

Indian Pediatr. 2011 Feb;48(2):135-7. doi: 10.1007/s13312-011-0039-4. Epub 2010 Nov 30.

Abstract

A long-term immunogenicity study of a single dose live attenuated H2 strain hepatitis A vaccine is being conducted in healthy Indian children at KEM Hospital, Pune. 131 of the original 143 children vaccinated in 2004, were evaluated for anti-HAV antibodies 30 months post vaccination (2007). Seroprotective antibody levels >20 mIU/mL were demonstrated in 87.8 % subjects with an overall GMT of 92.02 mIU/mL. No hepatitis like illness was recorded in any of the subjects since vaccination.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Antibodies, Viral / blood
  • Child
  • Child, Preschool
  • Female
  • Hepatitis A / blood
  • Hepatitis A / immunology*
  • Hepatitis A / prevention & control*
  • Hepatitis A Vaccines / administration & dosage*
  • Hepatitis A Vaccines / immunology*
  • Humans
  • Immunization Schedule
  • India
  • Male
  • Seroepidemiologic Studies
  • Vaccines, Attenuated / administration & dosage
  • Vaccines, Attenuated / immunology

Substances

  • Antibodies, Viral
  • Hepatitis A Vaccines
  • Vaccines, Attenuated