HIV-infected adolescents: relationship between atazanavir plasma levels and bilirubin concentrations

J Adolesc Health. 2011 Jan;48(1):100-2. doi: 10.1016/j.jadohealth.2010.05.009. Epub 2010 Aug 24.

Abstract

The use of atazanavir (ATV) in adolescents infected with human immunodeficiency virus was analyzed in this study. ATV morning plasma concentrations were determined during regular visits to the outpatient department. Results showed that bilirubin levels were higher among patients with higher ATV plasma concentrations (p = .018). Monitoring plasma levels of ATV could avoid toxicity in these patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adolescent Health Services
  • Anti-HIV Agents / administration & dosage
  • Atazanavir Sulfate
  • Bilirubin / blood*
  • Child
  • Drug Administration Schedule
  • Drug Monitoring
  • Female
  • HIV Infections / blood*
  • HIV Infections / drug therapy*
  • Humans
  • Hyperbilirubinemia / prevention & control
  • Male
  • Oligopeptides / administration & dosage*
  • Oligopeptides / blood*
  • Pyridines / administration & dosage*
  • Pyridines / blood*
  • Spain

Substances

  • Anti-HIV Agents
  • Oligopeptides
  • Pyridines
  • Atazanavir Sulfate
  • Bilirubin