Synthesis and antiviral evaluation of bisnoradamantane sulfites and related compounds

Med Chem. 2011 Mar;7(2):135-9. doi: 10.2174/157340611794859299.

Abstract

The reaction of a series of 1,2-diols with thionyl chloride led to bisnoradamantane sulfites in very good yields. The reaction has also been applied to related polycyclic scaffolds. The compounds have been tested for antiviral activity but none of them showed to be active. Several attempts to generate and trap SO from these polycyclic sulfites have been unsuccessful.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adamantane / analogs & derivatives*
  • Adamantane / chemical synthesis
  • Adamantane / chemistry
  • Adamantane / pharmacology*
  • Antiviral Agents / chemical synthesis*
  • Antiviral Agents / chemistry
  • Antiviral Agents / pharmacology*
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Sulfites / chemical synthesis
  • Sulfites / chemistry
  • Sulfites / pharmacology*
  • Viruses / drug effects*

Substances

  • Antiviral Agents
  • Sulfites
  • Adamantane