Autoinflammatory diseases and cardiovascular manifestations

Ann Med. 2011 Aug;43(5):341-6. doi: 10.3109/07853890.2010.547212. Epub 2011 Feb 1.

Abstract

Abstract A host of clinical scenarios can be depicted in hereditary autoinflammatory diseases, and the cardiovascular system can also be involved especially in familial Mediterranean fever (FMF), caused by mutations in the MEFV gene, and tumour necrosis factor receptor-associated periodic syndrome (TRAPS), caused by mutations in the TNFRSF1A gene. Pericardial diseases are the most represented cardiovascular abnormalities, though the role of MEFV and TNFRSF1A in the initiation of heart involvement has not been demonstrated formally and will be discussed herein.

Publication types

  • Review

MeSH terms

  • Cardiovascular Diseases / etiology*
  • Cardiovascular Diseases / physiopathology
  • Cytoskeletal Proteins / genetics
  • Familial Mediterranean Fever / complications*
  • Familial Mediterranean Fever / genetics
  • Familial Mediterranean Fever / physiopathology
  • Fever
  • Hereditary Autoinflammatory Diseases / complications*
  • Hereditary Autoinflammatory Diseases / genetics
  • Hereditary Autoinflammatory Diseases / physiopathology
  • Humans
  • Pericarditis / etiology
  • Pericarditis / physiopathology
  • Pyrin
  • Receptors, Tumor Necrosis Factor, Type I / genetics

Substances

  • Cytoskeletal Proteins
  • MEFV protein, human
  • Pyrin
  • Receptors, Tumor Necrosis Factor, Type I
  • TNFRSF1A protein, human

Supplementary concepts

  • Periodic fever, familial, autosomal dominant