Molecular mechanisms for lineage commitment in T cell development

E A Robey; B J Fowlkes; D M Pardoll

Molecular mechanisms for lineage commitment in T cell development

Semin Immunol. 1990 Jan;2(1):25-34.

Authors

E A Robey¹, B J Fowlkes, D M Pardoll

Affiliation

¹ Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.

PMID: 2129899

Abstract

Thymocyte development is characterized by the ordered expression of T cell receptors as well as the accessory molecules, CD4 and CD8. Interactions of these critical surface molecules with MHC ligands expressed on thymic stromal cells mediate additional developmental processes. Now that the stages of thymic differentiation have been delineated, current investigations are addressing the mechanisms that underlie T cell lineage commitment and selection.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

MeSH terms

Animals
CD4 Antigens / physiology
CD8 Antigens / physiology
Chromosome Mapping
Gene Rearrangement, T-Lymphocyte / genetics
Lymphocyte Activation / physiology*
Mice
Receptors, Antigen, T-Cell / biosynthesis
Receptors, Antigen, T-Cell / genetics
T-Lymphocytes / immunology
Thymus Gland / metabolism

Substances

CD4 Antigens
CD8 Antigens
Receptors, Antigen, T-Cell