In 8 patients aged 16-30 years with periapical osteolytic areas (1,5-2 cm) of anterior maxillary and mandibular teeth root canal treatment and apicoectomy were performed. The bone cavity following apicoectomy was filled with tricalcium phosphate ceramic (small spheres diameter more than 1 mm and less than 2 mm). Patients were re-examined the following day as well as on the 4th, 7th, and 15th postoperative day. Follow up at the 1, 3, 6, 12 and 18 postoperative months did not show any problem of the healed wood nor any rejection of the implanted material. Radiographically, some resorption of the material as well as new bone formation were noticed 12 and 18 month after the operation.