Abstract
The antimicrobial and hemolytic activities of a host defense peptide can be controlled by its modification as a propeptide of reduced net charge, which can then be processed by neutrophil elastase, a serine protease involved in chronic airway inflammation and infections associated with cystic fibrosis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cystic Fibrosis / microbiology*
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Hemolysis / drug effects
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Humans
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Leukocyte Elastase / genetics
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Leukocyte Elastase / metabolism*
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Peptides / metabolism*
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Peptides / pharmacology*
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Pseudomonas aeruginosa / drug effects
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Staphylococcus aureus / drug effects
Substances
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Peptides
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Leukocyte Elastase