Detecting microarray data supported microRNA-mRNA interactions

Int J Data Min Bioinform. 2010;4(6):639-55. doi: 10.1504/ijdmb.2010.037545.

Abstract

MicroRNAs (miRNAs) have been recently emerged as a novel class of endogenous post-transcriptional regulators in a variety of animal and plant species. Identifying bona fide miRNA-mRNA interactions is an important but challenging task for our insight into the regulatory mechanism of miRNAs. In this paper, we employ a variant of affinity propagation algorithm customised for bipartite graph to reveal the miRNA-mRNA interactions supported by microarray data. Our extensive experiments on human data sets show that our method performs effectively in screening the miRNA-mRNA interactions predicted by sequence-based approaches to reduce the number of candidate miRNA targets using microarray data.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • Genomics / methods*
  • Humans
  • MicroRNAs / chemistry*
  • MicroRNAs / metabolism
  • Microarray Analysis / methods*
  • RNA, Messenger / chemistry*
  • RNA, Messenger / metabolism
  • Sequence Analysis, RNA

Substances

  • MicroRNAs
  • RNA, Messenger