Re-dicing the pancreatic β-cell: do microRNAs define cellular identity?

EMBO J. 2011 Mar 2;30(5):797-9. doi: 10.1038/emboj.2011.31.

Abstract

A role for Dicer and miRNAs in regulating pancreatic β-cell differentiation and insulin production is discussed here in the broader context of miRNA functions in cell fate specification and cellular stress responses.

Publication types

  • Comment

MeSH terms

  • Cell Differentiation
  • DEAD-box RNA Helicases / metabolism*
  • Humans
  • Insulin / genetics
  • Insulin-Secreting Cells / cytology*
  • Insulin-Secreting Cells / metabolism
  • MicroRNAs / physiology*
  • RNA, Messenger / metabolism
  • Ribonuclease III / metabolism*

Substances

  • Insulin
  • MIRN148 microRNA, human
  • MIRN24 microRNA, human
  • MIRN26A microRNA, human
  • MicroRNAs
  • RNA, Messenger
  • DICER1 protein, human
  • Ribonuclease III
  • DEAD-box RNA Helicases