Selective treatment of hypoxic tumor cells in vivo: phosphate pre-prodrugs of nitro analogues of the duocarmycins

Angew Chem Int Ed Engl. 2011 Mar 7;50(11):2606-9. doi: 10.1002/anie.201004456. Epub 2011 Feb 17.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amines / chemistry*
  • Amines / pharmacology
  • Animals
  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / pharmacology
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Duocarmycins
  • Humans
  • Hypoxia
  • Indoles / chemistry*
  • Indoles / pharmacology
  • Mice
  • Molecular Structure
  • Prodrugs / chemistry*
  • Pyrrolidinones / chemistry
  • Pyrrolidinones / pharmacology

Substances

  • Amines
  • Antineoplastic Agents
  • Duocarmycins
  • Indoles
  • Prodrugs
  • Pyrrolidinones
  • duocarmycin A