Nickel-catalyzed reductive cyclization of organohalides

Hyejin Kim; Chulbom Lee

doi:10.1021/ol200455n

Nickel-catalyzed reductive cyclization of organohalides

Org Lett. 2011 Apr 15;13(8):2050-3. doi: 10.1021/ol200455n. Epub 2011 Mar 18.

Authors

Hyejin Kim¹, Chulbom Lee

Affiliation

¹ Department of Chemistry, Seoul National University, Seoul 151-747, South Korea.

PMID: 21417402
DOI: 10.1021/ol200455n

Abstract

A mild and convenient nickel-catalyzed method for free-radical cyclization of organohalides is described. The use of a NiCl(2)•DME/Pybox complex as the catalyst and zinc powder in methanol efficiently promotes the reductive cyclization of various unsaturated alkyl halides to give carbo-, oxa-, and azacycles as products in high yields.