Abstract
We report the first documented case of a posttraumatic fungal keratitis caused by Neosartorya udagawae. The patient was empirically treated with fluconazole until a corneal scraping grew an Aspergillus fumigatus-like fungus, and itraconazole therapy was then established. A sequence-based approach assigned the isolate to the species. Five months after completion of antifungal therapy, endophthalmitis occurred and orbital exenteration was necessary.
MeSH terms
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Adult
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Antifungal Agents / administration & dosage
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Corneal Diseases / drug therapy
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Corneal Diseases / microbiology*
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Corneal Diseases / pathology*
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Corneal Diseases / surgery
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DNA, Fungal / chemistry
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DNA, Fungal / genetics
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DNA, Ribosomal / chemistry
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DNA, Ribosomal / genetics
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DNA, Ribosomal Spacer / chemistry
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DNA, Ribosomal Spacer / genetics
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Debridement
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Fluconazole / administration & dosage
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Humans
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Itraconazole / administration & dosage
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Male
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Microbial Sensitivity Tests
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Microscopy
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Mycoses / diagnosis*
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Mycoses / drug therapy
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Mycoses / pathology*
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Mycoses / surgery
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Neosartorya / isolation & purification*
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Phylogeny
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Sequence Analysis, DNA
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Wounds and Injuries / complications*
Substances
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Antifungal Agents
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DNA, Fungal
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DNA, Ribosomal
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DNA, Ribosomal Spacer
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Itraconazole
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Fluconazole