Functional significance of B7-H1 expressed by human uveal melanoma cells

Mol Med Rep. 2011 Jan-Feb;4(1):163-7. doi: 10.3892/mmr.2010.397. Epub 2010 Nov 17.

Abstract

B7-H1, a recently described B7 family member, has been reported to negatively regulate T-cell function in most cancer cells. In this study, we sought to investigate B7-H1 expression in four uveal melanoma (UM) cells (OCM1, SP6.5, OM431 and VUP) to determine the functional significance of B7-H1 expression in T-cell immune response. Using flow cytometry (FCM), we demonstrated that SP6.5 cells had high B7-H1 protein expression, while the other three UM cell lines had none. However, all four UM cell lines expressed B7-H1 mRNA, as confirmed by reverse transcription-polymerase chain reaction. In co-culture experiments using B7-H1-expressing UM cells with T-cells, FCM to determine CD69 expression in T-cells revealed that SP6.5 cell-related B7-H1 inhibited T-cell activation. This effect was eliminated by B7-H1-targeted RNA interference. An Annexin V/PI double staining assay further showed that B7-H1 expressed by SP6.5 cells did not increase the apoptosis of T-cells, though it was found in a variety of other solid tumors. In conclusion, all the UM cell lines constitutively expressed B7-H1 mRNA, while B7-H1 protein was expressed at different levels. UM-related B7-H1 expression negatively regulated T-cell immune response through the inhibition of T-cell activation, and not through the promotion of T-cell apoptosis. This provides new insight into anti-tumor immunity against B7-H1-expressing UM cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antigens, CD / genetics
  • Antigens, CD / immunology*
  • Apoptosis
  • B7-H1 Antigen
  • Cell Line, Tumor
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Lymphocyte Activation
  • Melanoma / genetics
  • Melanoma / immunology
  • T-Lymphocytes / cytology
  • T-Lymphocytes / immunology*
  • Uveal Neoplasms / genetics
  • Uveal Neoplasms / immunology

Substances

  • Antigens, CD
  • B7-H1 Antigen
  • CD274 protein, human

Supplementary concepts

  • Uveal melanoma