Silver-catalyzed cycloisomerization of 1,n-allenynamides

Org Lett. 2011 Jun 3;13(11):2952-5. doi: 10.1021/ol201041h. Epub 2011 May 2.

Abstract

A variety of allenynamides can undergo cycloisomerization reactions in the presence of silver triflate thus leading to the formation of N-containing heterocycles incorporating cross-conjugated trienes. Access to new dienic 4-piperidinone and azepane motifs was achieved. An extension to one-pot tandem sequences involving silver-catalyzed cycloisomerization/Diels-Alder reaction was also examined.