Facioscapulohumeral muscular dystrophy gene in Dutch families is not linked to markers for familial adenomatous polyposis on the long arm of chromosome 5

C Wijmenga; R R Frants; O F Brouwer; H M van der Klift; P Meera Khan; G W Padberg

doi:10.1016/0022-510x(90)90245-i

Facioscapulohumeral muscular dystrophy gene in Dutch families is not linked to markers for familial adenomatous polyposis on the long arm of chromosome 5

J Neurol Sci. 1990 Feb;95(2):225-9. doi: 10.1016/0022-510x(90)90245-i.

Authors

C Wijmenga¹, R R Frants, O F Brouwer, H M van der Klift, P Meera Khan, G W Padberg

Affiliation

¹ Department of Neurology, University Hospital, Leiden, The Netherlands.

PMID: 2157824
DOI: 10.1016/0022-510x(90)90245-i

Abstract

Cosegregation of facioscapulohumeral muscular dystrophy (FSHD) and familial adenomatous polyposis (FAP) has been described in two small families. The gene for FAP is located on the long arm of chromosome 5. We studied two large Dutch families with FSHD and found no evidence for linkage with gene markers closely linked to FAP. These results strongly suggest that the FSHD gene segregating in the Dutch families is not localized close to the FAP locus on chromosome 5.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adenomatous Polyposis Coli / genetics*
Chromosomes, Human, Pair 5*
Facial Muscles / physiopathology*
Female
Genetic Linkage*
Humans
Male
Muscular Dystrophies / genetics*
Netherlands