Staphylococcus lugdunensis strain with a modified PBP1A/1B expressing resistance to β-lactams

S D Kotsakis; L S Tzouvelekis; L Zerva; A Liakopoulos; E Petinaki

doi:10.1007/s10096-011-1289-8

Staphylococcus lugdunensis strain with a modified PBP1A/1B expressing resistance to β-lactams

Eur J Clin Microbiol Infect Dis. 2012 Feb;31(2):169-72. doi: 10.1007/s10096-011-1289-8. Epub 2011 May 19.

Authors

S D Kotsakis¹, L S Tzouvelekis, L Zerva, A Liakopoulos, E Petinaki

Affiliation

¹ Department of Microbiology, University Hospital of Larissa, Larissa, Greece.

PMID: 21594555
DOI: 10.1007/s10096-011-1289-8

Abstract

We describe for the first time the emergence of an mecA-negative Staphylococcus lugdunensis strain with a modified PBP1A/1B that expresses resistance to all β-lactams. A duplication of the tetrapeptide S(569)AYG, which is part of the transpeptidase domain of PBP1A/1B and closely located to the K(583)TG catalytic motif, was associated with this unusual phenotype.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged, 80 and over
Anti-Bacterial Agents / pharmacology*
Endocarditis, Bacterial / microbiology
Female
Humans
Microbial Sensitivity Tests
Models, Molecular
Penicillin-Binding Proteins / chemistry
Penicillin-Binding Proteins / genetics*
Peptidyl Transferases / chemistry
Peptidyl Transferases / genetics*
Staphylococcal Infections / microbiology
Staphylococcus lugdunensis / drug effects*
Staphylococcus lugdunensis / genetics
Staphylococcus lugdunensis / isolation & purification
Staphylococcus lugdunensis / metabolism
beta-Lactam Resistance* / genetics
beta-Lactams / pharmacology

Substances

Anti-Bacterial Agents
Penicillin-Binding Proteins
beta-Lactams
Peptidyl Transferases