Enantioselective synthesis of diverse sulfinamides and sulfinylferrocenes from phenylglycine-derived chiral sulfinyl transfer agent

J Org Chem. 2011 Jul 1;76(13):5480-4. doi: 10.1021/jo200715c. Epub 2011 Jun 7.

Abstract

A new chiral sulfinyl transfer auxiliary derived from readily available phenylglycine was developed. This auxiliary is utilized to synthesize a diverse array of alkyl- and arylsulfinamides and sulfinylferrocenes in high yields and excellent ee's. The desired products are produced in a one-pot sequence from the oxathiazolidine 2-oxide by two sequential nucleophilic additions that proceed in a stereospecific manner.

MeSH terms

  • Amides / chemical synthesis*
  • Amides / chemistry
  • Ferrous Compounds / chemical synthesis*
  • Ferrous Compounds / chemistry
  • Glycine / analogs & derivatives
  • Glycine / chemistry*
  • Metallocenes
  • Molecular Structure
  • Stereoisomerism
  • Sulfhydryl Compounds / chemical synthesis*
  • Sulfhydryl Compounds / chemistry

Substances

  • Amides
  • Ferrous Compounds
  • Metallocenes
  • Sulfhydryl Compounds
  • Glycine
  • ferrocene